Greenfield Lab

The Greenfield lab currently has 3 ongoing projects. One of the projects focuses on inflammation in orthopedic aseptic implant loosening caused by wear and accumulation of implant particles. The goal of the project is to better understand and mitigate this inflammation through pharmacotherapies. This project is currently led by Stefanie Simpson. Another project seeks to evaluate the effect of the new antibiotic on biofilms in orthopedic joint implant infections using mice of implant infection model. This project is currently led by Shota Higashihira. The final project focuses on repurposing already FDA approved oncology drugs to treat metastatic osteosarcoma. Specifically, Romidepsin which is a histone deacetylase inhibitor that was identified as a promising therapeutic through a 3D in vitro spheroid method. The future directions for this project include determining whether romidepsin is effective in patient derived spheroids and also in a mouse model of osteosarcoma. The results of this project’s experiments could lead to a canine clinical trial. This project is currently led by Emily Elizabeth Seiden.

Supervisor: Ed Greenfield
Department: Orthopaedic Surgery